Sundowns have an shot at extending their top lead in Group B to three points.
Last Friday in Tshwane, the Brazilians shared the spoils in a thrilling 2-2 draw against the Sudanese giants, who are playing their home games away from home due to the civil war in Sudan.
MAMELODI SUNDOWNS STARTING LINE UP VS AL HILAL
Coach Miguel Cardoso has named his side to go all out in Rwanda, recalling some key players from recent fixtures.
The starting 11 is: Onyango; Khuliso Mudau, Keanu Cupido, Sibusiso Sibiya, Teboho Mokoena, Marcelo Allende, Nuno Santos, Brayan León, Tahsreeq Matthews, Arthur Sales, Ndamane.
More information to follow.